Recombinant human Thrombomodulin/BDCA-3 protein

Thrombomodulin, also known as CD141 or BDCA-3, is an endothelial cell-expressed, transmembrane glycoprotein that can form a complex with the coagulation factor, thrombin. This complex induce activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. Thrombomodulin-bound thrombin has procoagulant effect at the same time by inhibiting fibrinolysis by cleaving thrombin-activatable fibrinolysis inhibitor (TAFI) into its active form. Reduced levels of thrombomodulin or increased serum levels of THBD can correlate with pathogenesis of certain cardiovascular diseases, such as atherosclerosis and thrombosis. In addition, It associated with liver cirrhosis, diabetes mellitus, cerebral and myocardial infarction, and multiple sclerosis. Recombinant human Thrombomodulin, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.