Recombinant human C-Reactive/CRP protein
CRP, also known as C-reactive protein, is a member of the pentaxin family. This protein is found in the blood, its levels rise dramatically during inflammatory processes occurring in the body. This increment is due to a rise in the plasma concentration of IL-6, which is produced predominantly by macrophages as well as adipocytes. Its physiological role is to bind to lysophosphatidylcholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system via C1q. It is also play another important role in innate immunity, as an early defense system against infections. It has been shown that high levels of CRP in humans is associated with an increased risk of cardiovascular diseases. Recombinant human C-Reactive/CRP, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
C-reactive protein, C-reactive protein isoform 1, CRP, PTX1
Expression System
HEK293
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Absorbance at 280 nm)
Purity
> 90% by SDS - PAGE
Molecular Weight
24.1 kDa (215aa)
Additionnal Information
References & Citations
Pepys, MB., et al (2003) J Clin Invest. 111:1805-1812.; ; Danesh, J. et al (2004) N. Engl. J. Med. 350:1387-1397.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction, Metabolism
NCBI Accession Number
NP_000558.2
Uniprot Accession Number
P02741
Species
Human
N Terminal Sequence
Asp
AA Sequence
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