Recombinant mouse TIM-3/HAVCR2 protein
TIM-3, also known as HAVCR2 (epatitis A virus cellular receptor 2), belongs to TIM family cell surface receptor proteins.TIM-3 is up‑regulated on several populations of activated myeloid cells and T cells. It is an immune checkpoint and together with other inhibitory receptors including PD-1and LAG3 mediate the CD8+ T-cell exhaustion. Also, it is primarily activated by galectin-9. The engagement leads to stimulation of an influx of calcium to intracellular space and induction of programmed cell death, apoptosis. As a consequence, a suppression of Th1 and Th17 responses and induction of immune tolerance occurs. Recombinant mouse TIM-3, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
HEK293
Antigen Species
Human, Mouse
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS - PAGE
Molecular Weight
46.3kDa (413aa)
Additionnal Information
References & Citations
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_599011.2
Uniprot Accession Number
Q8VIM0
Species
Human, Mouse
N Terminal Sequence
Arg20
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