Recombinant human LBP protein
LBP, also known as Lipopolysaccharide-binding protein, is a glycoprotein member of the BPI/LBP family of lipid-binding proteins. LBP is a glycoprotein that is synthesized principally by hepatocytes. It binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. It binds to LPS to elicit immune responses by presenting the LPS to important cell surface pattern recognition receptors called CD14 and TLR4. Recombinant human LBP, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Lipopolysaccharide-binding protein, LBP, BPIFD2, MGC22233, LCD-binding protein, OTTHUMP00000030965
Expression System
HEK293
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
51.7kDa (462aa)
Additionnal Information
References & Citations
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_004130.2
Uniprot Accession Number
P18428
Species
Human
N Terminal Sequence
Ala 26
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