Recombinant human pIgR protein

PIgR, also known as polymeric immunoglobulin receptor, is responsible for transcytosis of soluble dimeric IgAs and immune. This protein binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, the cleavage occurs that separates the extracellular from the transmembrane segment. PIgR expression is under the strong regulation of cytokines, hormones, and pathogenic stimuli. The expression of pIgR is critically regulated by the pro-inflammatory cytokines, such as IL-1, IL-4, TNF-α, and IFN-γ. Recombinant human pIgR, fused to Histag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.