Recombinant human FGF-19 Protein

FGF-19, also known as fibroblast growth factor 19 , is a member of the FGF family. FGF-19 interacts with FGFR1, FGFR2, FGFR3 and FGFR4. This protein is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and EPK1/2 cascades. FGF-19 is a high affinity, heparin dependent ligand for FGFR4. It also stimulates glucose uptake in adiposytes. Recombinant human FGF-19, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Fibroblast growth factor 19, FGF19

Expression System

HEK293

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS - PAGE

Molecular Weight

23.0kDa (205aa)

Additionnal Information

, ATGP3972-10 µg, ATGP3972-20 µg, ATGP3972-50 µg, ATGP3972-100 µg, ATGP3972-250 µg, ATGP3972-500 µg, ATGP3972-1 mg, ATGP3972-10, ATGP3972-20, ATGP3972-50, ATGP3972-100, ATGP3972-250, ATGP3972-500, ATGP3972-1

References & Citations

Motylewska E., et al, (2018) Cytokine. 105:32-36.; ; Lang L., et al, (2019) Curr Cancer Drug Targets. 19:17-25.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid. In 20 mM Tris-HCl (pH8.0) containing 0.1M NaCl, 20% glycerol

Scientific Category

Signal Transduction, Hormones & Cytokines

NCBI Accession Number

NP_005108.1

Uniprot Accession Number

O95750

Species

Human

N Terminal Sequence

Asp

AA Sequence

RPLAF SDAGPHVHYG WGDPIRLRHL YTSGPHGLSS CFLRIRADGV VDCARGQSAH SLLEIKAVAL RTVAIKGVHS VRYLCMGADG KMQGLLQYSE EDCAFEEEIR PDGYNVYRSE KHRLPVSLSS AKQRQLYKNR GFLPLSHFLP MLPMVPEEPE DLRGHLESDM FSSPLETDSM DPFGLVTGLE AVRSPSFEK