Recombinant human FGF-19 Protein
FGF-19, also known as fibroblast growth factor 19 , is a member of the FGF family. FGF-19 interacts with FGFR1, FGFR2, FGFR3 and FGFR4. This protein is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and EPK1/2 cascades. FGF-19 is a high affinity, heparin dependent ligand for FGFR4. It also stimulates glucose uptake in adiposytes. Recombinant human FGF-19, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Fibroblast growth factor 19, FGF19
Expression System
HEK293
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS - PAGE
Molecular Weight
23.0kDa (205aa)
Additionnal Information
References & Citations
Motylewska E., et al, (2018) Cytokine. 105:32-36.; ; Lang L., et al, (2019) Curr Cancer Drug Targets. 19:17-25.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid. In 20 mM Tris-HCl (pH8.0) containing 0.1M NaCl, 20% glycerol
Scientific Category
Signal Transduction, Hormones & Cytokines
NCBI Accession Number
NP_005108.1
Uniprot Accession Number
O95750
Species
Human
N Terminal Sequence
Asp
AA Sequence
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