Recombinant mouse OX40/TNFRSF4 protein

TNFRSF4, also known as CD134, is a member of the TNFR-superfamily of receptors. This protein is a receptor for TNFSF4/OX40L/GP34 and a costimulatory molecule implicated in long-term T-cell immunity. OX40-OX40L interactions regulate antigen-specific T-cell expansion and survival, cytokine production. It also modulates cytokine receptor signalling. Therefore the interaction between TNFRSF4 and CD40L plays a key role in the development of multiple imflammatry and autoimmune disease. It has been implicated in the pathologic cytokine storm associated with certain viral infections, including the H5N1 bird flu. Recombinant mouse OX40/TNFRSF4 , fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Tumor necrosis factor receptor superfamily member 4, TNFRSF4, ACT35, CD134, IMD16, OX40, TXGP1L, ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor

Expression System

HEK293

Antigen Species

Mouse

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

48.6kDa (435aa)

Additionnal Information

, ATGP3971-10 µg, ATGP3971-20 µg, ATGP3971-50 µg, ATGP3971-100 µg, ATGP3971-250 µg, ATGP3971-500 µg, ATGP3971-1 mg, ATGP3971-10, ATGP3971-20, ATGP3971-50, ATGP3971-100, ATGP3971-250, ATGP3971-500, ATGP3971-1

References & Citations

Schreiber TH, et al, (2012) J Immunol. 189:3311-3318.; ; Webb GJ, et al, (2016) Clin Rev Allergy Immunol. 50:312-332.; ; Zhou B, et al, (2020) Transplant Proc. 52:398-405.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_035789.1

Uniprot Accession Number

P47741

Species

Mouse

N Terminal Sequence

Asp

AA Sequence

VTARRL NCVKHTYPSG HKCCRECQPG HGMVSRCDHT RDTLCHPCET GFYNEAVNYD TCKQCTQCNH RSGSELKQNC TPTQDTVCRC RPGTQPRQDS GYKLGVDCVP CPPGHFSPGN NQACKPWTNC TLSGKQTRHP ASDSLDAVCE DRSLLATLLW ETQRPTFRPT TVQSTTVWPR TSELPSPPTL VTPEGP