Recombinant Human IFN-alpha/beta R2/IFNAR2 protein
IFN-alpha/beta R2, also known as IFNAR2, is a member of the class II cytokine receptor family. This protein is the principal ligand binding subunit of the receptor. Ligand bindnig is stabilized by the subsequent association with IFNAR1 and forms the signaling compelx recptor. It also plays the role in STAT1, STAT2, and STAT3 activation. Recombinant human IFN-alpha/beta R2, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Specifications
Product Name Alternative
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.25 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Bioactivity
Molecular Weight
51.7kDa (456aa)
Additionnal Information
References & Citations
Grazziola C, et al, (2005) Int J Oncol 26:129-140.; ; Ortiz A, et al, (2019) Cancer Cell 35:33-45.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology, Hormones & Cytokines
NCBI Accession Number
NP_997468
Uniprot Accession Number
P48551
Species
Human
N Terminal Sequence
Ile
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