Recombinant Rat UNC5H2/UNC5B protein
UNC5B/UNC5B, also known as Netrin receptor UNC5B, is one of four related receptors that comprise the UNC5 family and serve as receptors for the axon guidance molecule Netrin-1. Outside of the nervous system, UNC5B facilitates Netrin-1-mediated inhibition of capillary branching and leukocyte migration, as well as Netrin-1-mediated promotion of osteoclast differentiation. Also this protein activates DAPK1 which mediates apoptosis. It is believed to play a role in tumorgenesis. Additionally, It is thought to play a critical role in the development of atherosclerosis and the survival of renal tubular epithelial cells during acute kidney injury. Recombinant Rat UNC5B/UNC5B, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
HEK293
Antigen Species
Rat
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
66.0kDa (590aa)
Additionnal Information
References & Citations
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_071543
Uniprot Accession Number
O08722
Species
Rat
N Terminal Sequence
Asp
AA Sequence
Frequently Asked Questions
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