Recombinant Human Placental Lactogen/CSH1 Protein

CSH1, also known as placental lactogen, is a member of the PRL/GH family. CSH1 gene is located on chromosome 17q which participates in the regulation of postnatal and intrauterine growth. This protein is produced only during preganancy and plays important role in increase of pancreatic islets. It also inhibits apoptosis of insulinoma cell lines by activating the phosphorylation of AKT protein. CSH1 activates PRLR through zinc-induced dimerization but does not interact with GHR. Recombinant human CSH1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Specifications

Human CSH1 stimulates cell proliferation of the Nb2-11 Rat lymphoma cells. The ED50 range ≤ 0.8 ng/mL.

Product Name Alternative

Chorionic somatomammotropin hormone 1 precursor, chorionic somatomammotropin A, choriomammotropin, placental lactogen, PL, chorionic somatomammotropin-1, Lactogen, CS-1, CSA, CSMT, CHB3, hcs-1, hcs-A, CSH1

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Bioactivity

Concentration

0.25 mg/mL (determined by Absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Bioactivity

Measured in a cell proliferation assay using Nb2-11 Rat lymphoma cells. The ED50 range ≤ 0.8 ng/mL.

Molecular Weight

23.1kDa (197aa)

Additionnal Information

, ATGP3948-10 µg, ATGP3948-20 µg, ATGP3948-50 µg, ATGP3948-100 µg, ATGP3948-250 µg, ATGP3948-500 µg, ATGP3948-1 mg, ATGP3948-10, ATGP3948-20, ATGP3948-50, ATGP3948-100, ATGP3948-250, ATGP3948-500, ATGP3948-1

References & Citations

Prager S., et al, (2003) Genet Test. 7:259-263.; ; Uemura S, et al, (2007) J Biol Chem. 282:8613-8621.; ; Awonuga AO, et al, (2011) Mol Reprod Dev. 78:519-528.;