Recombinant Mouse TrkC Protein

TrkC, also known as NT-3 growth factor receptor, is part of the large family of receptor tyrosine kinases. TrkC is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3) . As such, TrkC mediates the multiple effects of this neurotrophic factor, which includes neuronal differentiation and survival. Family of neurotrophin receptors including NTRK3 have been shown to induce a variety of pleiotorpic response in malignant cells, including enhanced tumor cell invasiveness and chemotoxis. Increased NTRK3 expression has been demonstrated in neuroblastoma, in medulloblastoma, and in neuroectodermal brain tumors. Recombinant mouse TrkC, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

NT-3 growth factor receptor, GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, Ntrk3, AW125844, Ntrk3_tv3, TrkC

Expression System

Baculovirus

Antigen Species

Mouse

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Absorbance at 280 nm)

Endotoxin

<1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

45.4kDa (404aa)

Additionnal Information

, ATGP3946-10 µg, ATGP3946-20 µg, ATGP3946-50 µg, ATGP3946-100 µg, ATGP3946-250 µg, ATGP3946-500 µg, ATGP3946-1 mg, ATGP3946-10, ATGP3946-20, ATGP3946-50, ATGP3946-100, ATGP3946-250, ATGP3946-500, ATGP3946-1

References & Citations

Wook jin., et al, (2010) Carcinogenesis. 11:1939-1947.; ; Garrett M B., et al, (2009) Clin Cancer Res. 15:3244-3250.; ; LD Huong., et al, (2012) Oral Diseases 18:513–519.