Recombinant human GDNF protein

GDNF, also known as Glial cell-derived neurotrophic factor, is a member of the GDNF family of ligands (GFL) . This Protein has been found that GFLs play a role in a number of biological processes including cell survival, neurite outgrowth, cell differentiation and cell migration. It promotes the survival of many types of neurons and signals through GFRa receptors, particularly GFRa1. These neuronal populations die in the course of Parkinson's disease and amyotrophic lateral sclerosis (ALS) . GDNF also regulates kidney development and spermatogenesis, and has a powerful and rapid negative (ameliorating) effect on alcohol consumption. Recombinant human GDNF, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Specifications

Human GDNF is coated at 0.5 µg/mL (100 ul/well) can bind Human GFR alpha-1 (CAT# ATGP4154) in a Functional ELISA assay.

Product Name Alternative

Glial cell line-derived neurotrophic factor, hGDNF, Astrocyte-derived trophic factor, ATF, ATF1, ATF2, HFB1-GDNF, HSCR3

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Bioactivity

Concentration

0.25 mg/mL (determined by Absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Bioactivity

Measured by its binding ability in a functional ELISA with Human GFR alpha-1 (CAT# ATGP4154) .

Molecular Weight

12.8kDa (113aa)

Additionnal Information

, ATGP3942-10 µg, ATGP3942-20 µg, ATGP3942-50 µg, ATGP3942-100 µg, ATGP3942-250 µg, ATGP3942-500 µg, ATGP3942-1 mg, ATGP3942-10, ATGP3942-20, ATGP3942-50, ATGP3942-100, ATGP3942-250, ATGP3942-500, ATGP3942-1