Recombinant human Hyaluronidase 1/HYAL1 protein

HYAL1, also known as Hyaluronidase-1, is a member of the endolytic glycoside hydrolase family. Human hyaluronidases (HYALs) are a group of five endoβNacetylhexosaminidases that include HYAL1, HYAL2, HYAL3, HYAL4, and SPAM1 (PH20) . HYAL1 preferentially degrades hyaluronic acid present in the extracellular matrix of somatic tissues. This protein is active at an acidic pH and is the major hyaluronidase in plasma. Defects in HYAL1 are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. It is implicated in several types of cancers, likely due to the angiogenic effects of HYAL1-cleaved hyaluronan fragments. Recombinant human HYAL1, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Hyaluronidase-1, Hyal-1, Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1, HYAL1, Hyaluronidase 1, Hyaluronoglucosaminidase 1, Hyaluronoglucosaminidase1, LUCA 1, MPS9, NAT6, Plasma hyaluronidase, Tumor suppressor LUCA 1

Expression System

HEK293

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

46.9kDa (420aa)

Additionnal Information

, ATGP3941-10 µg, ATGP3941-20 µg, ATGP3941-50 µg, ATGP3941-100 µg, ATGP3941-250 µg, ATGP3941-500 µg, ATGP3941-1 mg, ATGP3941-10, ATGP3941-20, ATGP3941-50, ATGP3941-100, ATGP3941-250, ATGP3941-500, ATGP3941-1

References & Citations

Csoka, A.B. et al. (2001) Matrix Biol. 20:499-508.; ; Jedrzejas, M. J. and Stern, R. (2005) Proteins 61:227-238.; ; Frost, GI. et al. (1997) Biochem. Biophys. Res. Commun. 236:10-15.;