Recombinant mouse HVEM/TNFRSF14 protein
HVEM/TNFRSF14, also known as tumor necrosis factor receptor superfamily member 14, is a member of TNF receptor superfamily. This protein was originally known as herpesvirus entry mediator A (HveA) ; HveB and HveC are structurally unrelated proteins of the immunoglobulin superfamily. The cytoplasmic region of this receptor was found to bind to several TNF receptor associated factor (TRAF) family members, which may mediate the signal transduction pathways that activate the immune response. It promotes and inhibits T cell activity. This protein signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation. It participates in cell to cell contact signaling between antigen presenting cells and lymphocytes. This protein downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response. Recombinant mouse HVEM/TNFRSF14, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
Baculovirus
Antigen Species
Mouse
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
45.3 kDa (407aa)
Additionnal Information
References & Citations
Choi EK., et al. (2013) J Endocrinol. 220:25-33.; ; Kotsiou E., et al. (2018) Blood. 128:72-81.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_849262.1
Uniprot Accession Number
Q80WM9
Species
Mouse
N Terminal Sequence
Gln39
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