Recombinant mouse CCL21/6Ckine protein
CCL21, also known as C-C motif chemokine 21a, is a member of homeostatic chemokine. It plays an importantrole in adaptive immune responses and inflammation. This protein Inhibits hemopoiesis and stimulates chemotaxis.It is involved in signaling through CXCR3. This protein is upregulated on local vascular endothelial cells, macrophages, T cells, and neurons during chronic inflammation or tissue damage. Deficient of This protein was impaired in the medullary deletion of self-reactive thymocytes and developed autoimmune dacryoadenitis and T cellaccumulation in the lymph nodes was also defective. Recombinant mouse CCL21, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
Baculovirus
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
13.1 kDa (119aa)
Additionnal Information
References & Citations
Kozai M., et al. (2017) J Exp Med. 214:1925-1935. ; ; Chen SC., et al. (2002) J Immunol. 168:1001-1008.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Cardiovascular
NCBI Accession Number
NP_035254
Uniprot Accession Number
P84444
Species
Mouse
N Terminal Sequence
Ala
AA Sequence
SDGGGQD CCLKYSQKKI PYSIVRGYRK QEPSLGCPIP AILFSPRKHS KPELCANPEE GWVQNLMRRL DQPPAPGKQS PGCRKNRGTS KSGKKGKGSK GCKRTEQTQP SRG
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