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Recombinant mouse CCL21/6Ckine protein

CCL21, also known as C-C motif chemokine 21a, is a member of homeostatic chemokine. It plays an importantrole in adaptive immune responses and inflammation. This protein Inhibits hemopoiesis and stimulates chemotaxis.It is involved in signaling through CXCR3. This protein is upregulated on local vascular endothelial cells, macrophages, T cells, and neurons during chronic inflammation or tissue damage. Deficient of This protein was impaired in the medullary deletion of self-reactive thymocytes and developed autoimmune dacryoadenitis and T cellaccumulation in the lymph nodes was also defective. Recombinant mouse CCL21, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

C-C motif chemokine ligand 21A, 6Ckine, Beta-chemokine exodus-2, Small-inducible cytokine A21a, Scya21, Scya21a, Thymus-derived chemotactic agent 4, TCA4, 6CKBAC2, ALP, CKb9, Gm1987, SLC

Expression System

Baculovirus

Antigen Species

Mouse

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

13.1 kDa (119aa)

Additionnal Information

CCL21Ckine, ATGP3900-10 µg, ATGP3900-20 µg, ATGP3900-50 µg, ATGP3900-100 µg, ATGP3900-250 µg, ATGP3900-500 µg, ATGP3900-1 mg, ATGP3900-10, ATGP3900-20, ATGP3900-50, ATGP3900-100, ATGP3900-250, ATGP3900-500, ATGP3900-1

References & Citations

Kozai M., et al. (2017) J Exp Med. 214:1925-1935. ; ; Chen SC., et al. (2002) J Immunol. 168:1001-1008.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Cardiovascular

NCBI Accession Number

NP_035254

Uniprot Accession Number

P84444

Species

Mouse

N Terminal Sequence

Ala

AA Sequence

SDGGGQD CCLKYSQKKI PYSIVRGYRK QEPSLGCPIP AILFSPRKHS KPELCANPEE GWVQNLMRRL DQPPAPGKQS PGCRKNRGTS KSGKKGKGSK GCKRTEQTQP SRG

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