Recombinant mouse CCL21/6Ckine protein

CCL21, also known as C-C motif chemokine 21a, is a member of homeostatic chemokine. It plays an importantrole in adaptive immune responses and inflammation. This protein Inhibits hemopoiesis and stimulates chemotaxis.It is involved in signaling through CXCR3. This protein is upregulated on local vascular endothelial cells, macrophages, T cells, and neurons during chronic inflammation or tissue damage. Deficient of This protein was impaired in the medullary deletion of self-reactive thymocytes and developed autoimmune dacryoadenitis and T cellaccumulation in the lymph nodes was also defective. Recombinant mouse CCL21, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.