Recombinant human FGF R2 beta (lllb) protein

FGF R2 beta (lllb), also known as fibroblast growth factor receptor 2 isoform 9, is a member of the fibroblast growth factor receptor family. This protein has important roles in embryonic development and tissue repair, especially bone and blood vessels. Like the other members of the fibroblast growth factor receptor family, these receptors signal by binding to their ligand and dimerisation (pairing of receptors), which causes the tyrosine kinase domains to initiate a cascade of intracellular signals. On a molecular level these signals mediate cell division, growth and differentiation. Also, it is required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Mutations in FGF R2 beta are associated with numerous medical conditions that include abnormal bone development (e.g. craniosynostosis syndromes: Apert syndrome, Antley-Bixler syndrome, Pfeiffer syndrome, Crouzon syndrome, Jackson-Weiss syndrome) and cancer. (e.g. Breast cancer, endometrial cancer and melanoma) Recombinant Human FGF R2 beta (lllb), fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.