Recombinant human Activin RIA/ALK-2 protein

Activin RIA, also known as Activin receptor type-1, is a member of TGF-beta serine/threonine kinase receptor family. It forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. This protein is involved for left-right pattern formation during embryogenesis. Also, it is important in the bone morphogenic protein (BMP) pathway which is responsible for the development and repair of the skeletal system. It has been connected to Fibrodysplasia Ossificans Progressiva, a disease characterized by the formation of heterotopic bone throughout the body. Recombinant Human Activin RIA, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

ACVR1, ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI, Activin receptor type I, Activin receptor-like kinase 2, ACTR-I, ALK-2, TSR-I, Serine/threonine-protein kinase receptor R1, TGF-B superfamily receptor type I

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

38.4 kDa (342aa)

Additionnal Information

Activin RIA, ALK2, ATGP3898-10 µg, ATGP3898-20 µg, ATGP3898-50 µg, ATGP3898-100 µg, ATGP3898-250 µg, ATGP3898-500 µg, ATGP3898-1 mg, ATGP3898-10, ATGP3898-20, ATGP3898-50, ATGP3898-100, ATGP3898-250, ATGP3898-500, ATGP3898-1, ATGP3898-10 µg, ATGP3898-20 µg, ATGP3898-50 µg, ATGP3898-100 µg, ATGP3898-250 µg, ATGP3898-500 µg, ATGP3898-1 mg, ATGP3898-10, ATGP3898-20, ATGP3898-50, ATGP3898-100, ATGP3898-250, ATGP3898-500, ATGP3898-1