Recombinant mouse FGF-21 protein

FGF-21, also known as fibroblast growth factor 21, is a member of the fibroblast growth factor family. It has a hydrophobic amino terminus, which is a typical signal sequence, and appears to be a secreted protein. It stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression. Recombinant mouse FGF-21, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

FGF 21, FGF-21, Fgf21, FGF21_HUMAN, FGFL, Fibroblast growth factor 21, PRO10196, UNQ3115

Expression System

E.coli

Antigen Species

Mouse

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

22.5 kDa (206aa) confirmed by MALDI-TOF

Additionnal Information

FGF21, ATGP3897-10 µg, ATGP3897-20 µg, ATGP3897-50 µg, ATGP3897-100 µg, ATGP3897-250 µg, ATGP3897-500 µg, ATGP3897-1 mg, ATGP3897-10, ATGP3897-20, ATGP3897-50, ATGP3897-100, ATGP3897-250, ATGP3897-500, ATGP3897-1, ATGP3897-10 µg, ATGP3897-20 µg, ATGP3897-50 µg, ATGP3897-100 µg, ATGP3897-250 µg, ATGP3897-500 µg, ATGP3897-1 mg, ATGP3897-10, ATGP3897-20, ATGP3897-50, ATGP3897-100, ATGP3897-250, ATGP3897-500, ATGP3897-1

References & Citations

Kharitonenkov A., et al. (2005) J Clin Invest. 115:1627-1635.; ; Yamauchi H., et al. (2006) EMBO Rep. 7:649-654.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Growth factors

NCBI Accession Number

NP_064397

Uniprot Accession Number

Q9JJN1

Species

Mouse

AA Sequence

AYPIPD SSPLLQFGGQ VRQRYLYTDD DQDTEAHLEI REDGTVVGAA HRSPESLLEL KALKPGVIQI LGVKASRFLC QQPDGALYGS PHFDPEACSF RELLLEDGYN VYQSEAHGLP LRLPQKDSPN QDATSWGPVR FLPMPGLLHE PQDQAGFLPP EPPDVGSSDP LSMVEPLQGR SPSYAS