Recombinant human IFN-alpha/beta R1/IFNAR1 protein
IFN-alpha/beta R1, also known as interferon alpha/beta receptor 1 (IFNAR1), is a member of the class II cytokine receptor family of proteins that form heterodimeric receptor complexes. These receptors are shared and served multiple functions. IFNAR1 and IFNBR1, in association with IFNAR2 and IFNBR2, is required for propagating anti-microbial signal transduction triggered by the type 1 interferons such as IFN-alpha and IFN-beta. Also, binding and activation of it stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Recombinant Human IFN-alpha/beta R1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
47.9 kDa (415aa)
Additionnal Information
References & Citations
Richter MF., et al, (1998) J Biol Chem. 273:24723-24729.; ; Claudinon J., et al, (2009) J. Biol. Chem. 284:24328-24340.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_000620
Uniprot Accession Number
P17181
Species
Human
N Terminal Sequence
Lys28
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