Recombinant human Sulfatase Modifying Factor 1/SUMF1 protein

SUMF1, also known as sulfatase-modifying factor 1 isoform 1, is a Ca2+-binging member of the sulfatase-modifying factor family. This protein as soluble ER lumenal glycoprotein converts inactive sulfatases into an active form by transforming a catalytic site cysteine into a formylglycine residue. In the ER, it can exist as either a monomer, or a disulfide-linked homodimer or a heterodimer with SUMF2. The genetic defect of FGly formation caused by mutations in the SUMF1 gene results in inactive FGE, and subsequently multiple sulfatase deficiency, a lysosomal storage disorder. Recombinant Human SUMF1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

SUMF1, AAPA3037, FGE, UNQ3037, Formylglycine-generating enzyme, C-alpha-formylglycine-generating enzyme 1, Sulfatase-modifying factor 1

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 85% by SDS-PAGE

Molecular Weight

38.1 kDa (347aa)

Additionnal Information

UNQ3037, SUMF1, SUMF 1, Sulfatase-modifying factor1, Sulfatase-modifying factor 1, Sulfatase modifying factor1, Sulfatase modifying factor 1, Formylglycine-generating enzyme, Formylglycine generating enzyme, FGE, C-alpha-formylglycine-generating enzyme1, C-alpha-formylglycine-generating enzyme 1, C alpha formylglycine generating enzyme1, C alpha formylglycine generating enzyme 1, AAPA3037, ATGP3893-10 µg, ATGP3893-20 µg, ATGP3893-50 µg, ATGP3893-100 µg, ATGP3893-250 µg, ATGP3893-500 µg, ATGP3893-1 mg, ATGP3893-010, ATGP3893-020, ATGP3893-050, ATGP3893-100, ATGP3893-250, ATGP3893-500, ATGP3893-01M