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Recombinant human CD21 protein

CD21, also known as complement receptor type 2 isoform 2, is an N-glycosylated member of the regulators of complement activation family of proteins. This protein is present on all mature B-cells and some T-cells and follicular dendritic cells and is released by proteolytic shedding from activated B cell. It forms a complex with the B cell receptor-associated CD19 molecule and lowers the threshold for B cell activation. It binds the complement component fragments iC3b, C3D, and C3d. Also, this protein has a function in the complement system through serving as the cellular receptor specific for ligands such as C3 and C4. Recombinant Human CD21, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

CD21, CR2, Cr2, C3DR, CR, CVID7, SLEB9, Complement receptor type 2, Complement C3d receptor, Epstein-Barr virus receptor, EBV receptor

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

105.2 kDa (959aa)

Additionnal Information

CD21, ATGP3887-10 µg, ATGP3887-20 µg, ATGP3887-50 µg, ATGP3887-100 µg, ATGP3887-250 µg, ATGP3887-500 µg, ATGP3887-1 mg, ATGP3887-10, ATGP3887-20, ATGP3887-50, ATGP3887-100, ATGP3887-250, ATGP3887-500, ATGP3887-1, ATGP3887-10 µg, ATGP3887-20 µg, ATGP3887-50 µg, ATGP3887-100 µg, ATGP3887-250 µg, ATGP3887-500 µg, ATGP3887-1 mg, ATGP3887-10, ATGP3887-20, ATGP3887-50, ATGP3887-100, ATGP3887-250, ATGP3887-500, ATGP3887-1

References & Citations

Tanner J., et al, (1987) Cell 50:203-213.; ; Carel JC., et al, (1990) J. Biol. Chem. 265:12293.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_001868.2

Uniprot Accession Number

P20023

Species

Human

N Terminal Sequence

Ile21

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