Recombinant human CD21 protein
CD21, also known as complement receptor type 2 isoform 2, is an N-glycosylated member of the regulators of complement activation family of proteins. This protein is present on all mature B-cells and some T-cells and follicular dendritic cells and is released by proteolytic shedding from activated B cell. It forms a complex with the B cell receptor-associated CD19 molecule and lowers the threshold for B cell activation. It binds the complement component fragments iC3b, C3D, and C3d. Also, this protein has a function in the complement system through serving as the cellular receptor specific for ligands such as C3 and C4. Recombinant Human CD21, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
CD21, CR2, Cr2, C3DR, CR, CVID7, SLEB9, Complement receptor type 2, Complement C3d receptor, Epstein-Barr virus receptor, EBV receptor
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
105.2 kDa (959aa)
Additionnal Information
References & Citations
Tanner J., et al, (1987) Cell 50:203-213.; ; Carel JC., et al, (1990) J. Biol. Chem. 265:12293.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_001868.2
Uniprot Accession Number
P20023
Species
Human
N Terminal Sequence
Ile21
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
