Recombinant human CTHRC1 protein

CTHRC1, also known as collagen triple helix repeat-containing protein 1 isoform 1, is a secreted glycoprotein that is expressed on renal epithelium, neurons, osteoblasts, and smooth muscle cells. This protein is overexpressed in different kinds of cancer tissues and promotes tumor formation. It acts as a negative regulator of collagen matrix deposition and is involved in cell migration, motility and invasion. The hormonal functions of CTHRC1 include regulation of lipid storage and cellular glycogen levels with potentially far-reaching implications for cell metabolism and physiology. Additionally, CTHRC1 increases bone mass as a positive regulator of osteoblastic bone formation and offers an anabolic approach for the treatment of osteoporosis. Recombinant human CTHRC1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.