Recombinant human Chemerin protein
Chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), is a distant member of the Cystatin superfamily. It is involved in multiple cancers, including adrenocortical carcinoma (ACC) . This protein in serum is transcriptionally downregulated in multiple cancer types. On the other hands, overexpression of this protein inhibits Wnt/beta-catenin pathway activity by promoting beta-catenin phosphorylation and degradation. Also, it has been implicated in autocrine/paracrine signaling for adipocyte differentiation and also stimulation of lipolysis. It was found to stimulate chemotaxis of dendritic cells and macrophages to the site of inflammation. Recombinant human Chemerin protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Retinoic acid receptor responder protein 2, RARRES2, HP10433, TIG2
Expression System
HEK293
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
16.6 kDa (143aa)
Additionnal Information
References & Citations
Reverchon M., et al, (2014) Biol Reprod. 90:102.; ; Liu-Chittenden Y., et al, (2016) J Clin Endocrinol Metab. 101 (9) :3345-3352.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Cardiovascular
NCBI Accession Number
NP_002880.1
Uniprot Accession Number
Q99969
Species
Human
N Terminal Sequence
Glu21
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