Recombinant human Chemerin protein

Chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), is a distant member of the Cystatin superfamily. It is involved in multiple cancers, including adrenocortical carcinoma (ACC) . This protein in serum is transcriptionally downregulated in multiple cancer types. On the other hands, overexpression of this protein inhibits Wnt/beta-catenin pathway activity by promoting beta-catenin phosphorylation and degradation. Also, it has been implicated in autocrine/paracrine signaling for adipocyte differentiation and also stimulation of lipolysis. It was found to stimulate chemotaxis of dendritic cells and macrophages to the site of inflammation. Recombinant human Chemerin protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.