Recombinant human Reg4 protein
Reg4, also known regenerating islet-derived protein 4, a member of the regenerating gene family belonging to the calcium (C-type) dependent lectin superfamily. It is calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. This protein is involved in inflammatory and metaplastic responses because expression of this protein is increased within or near inflammation, dysplasia and metaplasia of the GI epithelium. And this protein is highly expressed in the gastrointestinal tract and markedly up-regulated in colon adenocarcinoma, pancreatic cancer, gastric adenocarcinoma, and inflammatory bowel disease. Recombinant human Reg4 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Regenerating islet-derived protein 4 isoform 1, REG4, GISP, REG-IV, RELP
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
17 kDa (145aa)
Additionnal Information
References & Citations
Kawasaki Y., et al, (2015) Sci Rep. 5:14291.; ; Jin J., et al, (2017) Med Sci Monit. 23:3715-3721.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_114433
Uniprot Accession Number
Q9BYZ8
Species
Human
N Terminal Sequence
Ala
AA Sequence
DIIMRPS CAPGWFYHKS NCYGYFRKLR NWSDAELECQ SYGNGAHLAS ILSLKEASTI AEYISGYQRS QPIWIGLHDP QKRQQWQWID GAMYLYRSWS GKSMGGNKHC AEMSSNNNFL TWSSNECNKR QHFLCKYRP
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