What is the catalog number for Recombinant human Cathepsin Z protein?

The catalog number for Recombinant human Cathepsin Z protein is ATGP3848-010.

What sizes are available for Recombinant human Cathepsin Z protein?

Recombinant human Cathepsin Z protein is available in the following size(s): 10 µg.

Is Recombinant human Cathepsin Z protein in stock?

Recombinant human Cathepsin Z protein is currently made to order / not held in immediate stock. Contact us for lead time.

Recombinant human Cathepsin Z protein

Cathepsin Z, also known Cathepsin X and Cathepsin P, is a member of the C1 family of lysosomal cysteine proteases. It exhibits carboxy-monopeptidase and carboxy-dipeptidase activity. This protein regulates maturation of dendritic cells and plays important role in the initiation of adaptive immunity. It is also involved in tumor and immune cells as higher expression is found in tumour and immune cells of prostate and gastric carcinomas and inmacrophages of gastric mucosa. Recombinant human Cathepsin Z protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Specifications

Specific activity is > 1,400 pmol/min/ug in which one unit will convert 1.0 pmole of Mca-PLGL-Dpa-AR-NH2 to MCA- Pro-Leu-OH per minute at pH 3.5 at 25C.

Product Name Alternative

Carboxypeptidase LB, Cathepsin B2, Cathepsin IV, Cathepsin P, Cathepsin X, Cathepsin Y, Cathepsin Z, Cathepsin Z preproprotein, Cathepsin Z1, CatX, CTSP, CTSX, CTSZ, Cysteine-type carboxypeptidase, Lysosomal carboxypeptidase B

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Enzyme Activity

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Bioactivity

Specific activity is > 1,400pmol/min/ug in which one unit will convert 1.0pmole of Mca-PLGL-Dpa-AR-NH2 to MCA- Pro-Leu-OH per minute at pH 3.5 at 25C.

Molecular Weight

32.5 kDa (288aa)

Additionnal Information

Carboxypeptidase LB, Cathepsin B2, Cathepsin IV, Cathepsin P, Cathepsin X, Cathepsin X Z P, Cathepsin X, Z, P, Cathepsin X/Z/P, Cathepsin XZP, Cathepsin Y, Cathepsin Z, Cathepsin Z preproprotein, Cathepsin Z1, Cathepsin-IV, Cathepsin-X, Cathepsin-Y, Cathepsin-Z, Cathepsin-Z1, Cathepsin-B2, CatX, CTSP, CTSX, CTSZ, Cysteine-type carboxypeptidase, Lysosomal carboxypeptidase B, ATGP3848-10 µg, ATGP3848-20 µg, ATGP3848-50 µg, ATGP3848-100 µg, ATGP3848-250 µg, ATGP3848-500 µg, ATGP3848-1 mg, ATGP3848-010, ATGP3848-020, ATGP3848-050, ATGP3848-100, ATGP3848-250, ATGP3848-500, ATGP3848-01M

References & Citations

Akkari L., et al, (2014) Genes Dev. 28:2134-2150.; ; Allan ERO., et al, (2017) J Neuroinflammation. 14:103.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Cancer

NCBI Accession Number

NP_001327

Uniprot Accession Number

Q9UBR2

Species

Human

N Terminal Sequence

Gly24

AA Sequence

GLYFRRGQTC YRPLRGDGLA PLGRSTYPRP HEYLSPADLP KSWDWRNVDG VNYASITRNQ HIPQYCGSCW AHASTSAMAD RINIKRKGAW PSTLLSVQNV IDCGNAGSCE GGNDLSVWDY AHQHGIPDET CNNYQAKDQE CDKFNQCGTC NEFKECHAIR NYTLWRVGDY GSLSGREKMM AEIYANGPIS CGIMATERLA NYTGGIYAEY QDTTYINHVV SVAGWGISDG TEYWIVRNSW GEPWGERGWL RIVTSTYKDG KGARYNLAIE EHCTFGDPIV LEHHHHHH