Recombinant human MMP-9 protein
MMP9, also known matrix metalloproteinase-9, is one of the matrix metalloproteinases superfamily which is zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. It degrades many substrates such as gelatin, collagens, elastin and proteoglycan core protein which appears to be involved in invasive ability. This protein also plays an essential role in leukocyte migration and in bone osteoclastic resorption. It plays an important role in angiogenesis and neovascularization and so appears to be involved in the remodeling associated with malignant glioma neovascularization. Recombinant human MMP9 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Matrix metalloproteinase-9, MMP-9, CLG4B, GELB, MANDP2, Gelatinase B, 92kDa gelatinase, 92kDa type IV collagenaseANDP2, MMP-9
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
77.1 kDa (694aa)
Additionnal Information
References & Citations
Lee YD., et al, (2014) BMB Rep. 47:262-267.; ; Matin S., et al, (2018) Int J Chron Obstruct Pulmon Dis. 13:1449-1454.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Cardiovascular
NCBI Accession Number
NP_004985.2
Uniprot Accession Number
P14780
Species
Human
N Terminal Sequence
Ala20
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