Recombinant human Kallikrein 10/KLK10 protein

KLK10, also known as kallikrein-10, is belong to the subgroup of serine proteases encompassing fifteen homologous members. This protein is widely expressed in normal human organs, for example breast, prostate, thyroid, testis, ovary, and gastrointestinal tract. Interestingly, it is highly expressed in the islets of Langerhans in human pancreas. Also, it is detectable in many biological fluids, including milk, seminal plasma, amniotic fluid, serum, and cerebrospinal fluid. In spite of its unknown physiological functions, the implications of KLK10 in various diseases have been explored. Early studies have shown that this expression is dramatically down-regulated in breast and testicular germ-cell tumors. It is secreted and may play a role in suppression of tumorigenesis in breast. Recombinant human KLK10, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.