Recombinant human PDCD4 protein
PDCD4, also known as Programmed cell death 4, encodes a tumor suppressor protein whose expression is lost in progressed carcinomas of lung, breast, colon, and prostate. The expression of PDCD4 gene is strongly induced during apoptosis in a number of cell types. It is modulated by cytokines in natural killer and T cells. Recombinant human PDCD4, was expressed in E. coli and purified by conventional chromatography techniques.
Product Specifications
Product Name Alternative
Programmed cell death protein 4 isoform 1, H731
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
51.7 kDa (469aa)
Additionnal Information
References & Citations
Yoshinaga H., et al. (1999) Pathol lnt. 49 (12) :1067-77; ; Palamarchuk A., et al. (2005) Cancer Res. 65 (24) :11282-6.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 1mM DTT
Scientific Category
Cancer
NCBI Accession Number
NP_055271
Uniprot Accession Number
Q53EL6
Species
Human
AA Sequence
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