Recombinant human FGF receptor 1/FGFR1 protein

FGFR1b, also known as fibroblast growth factor receptor 1 isoform 4, is a member members of the fibroblast growth factor family. It is required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Signaling of this protein is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. Recombinant human FGFR1b protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Fibroblast growth factor receptor 1 isoform 1, FGFR-1, Basic fibroblast growth factor receptor 1, BFGFR, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr, CD331, CEK, FGFBR, FLG, HBGFR, KAL2, Pfeiffer syndrome

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

30.4 kDa (272aa)

Additionnal Information

FGF R1 Kinase Domain, Fibroblast growth factor receptor 1 isoform 4, FGFR1b, FGFR1, bFGF-R-1, BFGFR, CD331, CEK, ECCL, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD, ATGP3828-10 µg, ATGP3828-20 µg, ATGP3828-50 µg, ATGP3828-100 µg, ATGP3828-250 µg, ATGP3828-500 µg, ATGP3828-1 mg, ATGP3828-10, ATGP3828-20, ATGP3828-50, ATGP3828-100, ATGP3828-250, ATGP3828-500, ATGP3828-1

References & Citations

Lee JM., et al, (2008) Dev Biol. 314:341-350.; ; Xu R., et al, (2013) FEBS J. 280:2260-2270.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Cardiovascular

NCBI Accession Number

NP_075594

Uniprot Accession Number

P11362

Species

Human

N Terminal Sequence

Arg22

AA Sequence

RPSPTLPEQD ALPSSEDDDD DDDSSSEEKE TDNTKPNPVA PYWTSPEKME KKLHAVPAAK TVKFKCPSSG TPNPTLRWLK NGKEFKPDHR IGGYKVRYAT WSIIMDSVVP SDKGNYTCIV ENEYGSINHT YQLDVVERSP HRPILQAGLP ANKTVALGSN VEFMCKVYSD PQPHIQWLKH IEVNGSKIGP DNLPYVQILK TAGVNTTDKE MEVLHLRNVS FEDAGEYTCL AGNSIGLSHH SAWLTVLEAL EERPAVMTSP LYLELEHHHH HH