Recombinant human CD71/TFRC protein

TFRC, also known as transferrin receptor protein 1, is a transmembrane glycoprotein composed of two disulfide-linked monomers joined by two disulfide bonds. It acts as cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. This protein is necessary for development of erythrocytes and the nervous system. And it is positively regulates T and B cell proliferation through iron uptake. Recombinant human TFRC protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

TRFR, Transferrin receptor protein 1 isoform 1, Transferrin receptor protein 1, TR, TFRC, TFR-1, TFR1, TFR 1, TFR, T9, p90, IMD46, CD71, CD 71

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

74.9 kDa (669aa)

Additionnal Information

TRFR, Transferrin receptor protein 1 isoform 1, Transferrin receptor protein 1, TR, TFRC, TFR-1, TFR1, TFR 1, TFR, T9, p90, IMD46, CD71, CD 71, ATGP3825-10 µg, ATGP3825-20 µg, ATGP3825-50 µg, ATGP3825-100 µg, ATGP3825-250 µg, ATGP3825-500 µg, ATGP3825-1 mg, ATGP3825-010, ATGP3825-020, ATGP3825-050, ATGP3825-100, ATGP3825-250, ATGP3825-500, ATGP3825-01M

References & Citations

Laube F., et al, (2017) Anticancer Res. 37:3001-3007.; ; Zhou JH., et al, (2017) J Neurosci. 37:11335-11352.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Cardiovascular

NCBI Accession Number

NP_001121620

Uniprot Accession Number

P02786

Species

Human

N Terminal Sequence

Ala

AA Sequence

ADPLAGTESP VREEPGEDFP AARRLYWDDL KRKLSEKLDS TDFTGTIKLL NENSYVPREA GSQKDENLAL YVENQFREFK LSKVWRDQHF VKIQVKDSAQ NSVIIVDKNG RLVYLVENPG GYVAYSKAAT VTGKLVHANF GTKKDFEDLY TPVNGSIVIV RAGKITFAEK VANAESLNAI GVLIYMDQTK FPIVNAELSF FGHAHLGTGD PYTPGFPSFN HTQFPPSRSS GLPNIPVQTI SRAAAEKLFG NMEGDCPSDW KTDSTCRMVT SESKNVKLTV SNVLKEIKIL NIFGVIKGFV EPDHYVVVGA QRDAWGPGAA KSGVGTALLL KLAQMFSDMV LKDGFQPSRS IIFASWSAGD FGSVGATEWL EGYLSSLHLK AFTYINLDKA VLGTSNFKVS ASPLLYTLIE KTMQNVKHPV TGQFLYQDSN WASKVEKLTL DNAAFPFLAY SGIPAVSFCF CEDTDYPYLG TTMDTYKELI ERIPELNKVA RAAAEVAGQF VIKLTHDVEL NLDYERYNSQ LLSFVRDLNQ YRADIKEMGL SLQWLYSARG DFFRATSRLT TDFGNAEKTD RFVMKKLNDR VMRVEYHFLS PYVSPKESPF RHVFWGSGSH TLPALLENLK LRKQNNGAFN ETLFRNQLAL ATWTIQGAAN ALSGDVWDID NEFHHHHHH