Recombinant human IL-18R alpha/IL18R1 protein

IL18R1, also known as interleukin 18 receptor 1, is an interleukin receptor of the immunoglobulin superfamily. This protein contain three Ig-like C2-type (immunoglobulin-like) domains and on TIR domain. It shares numerous immuno-regulatory functions with IL12. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. Also, this receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. It binds to the agonist leads to the activation of NF-kappa-B, but does not bind IL1A or IL1B beta. Recombinant human IL18R1, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Interleukin-18 receptor 1, CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein, IL-1Rrp, IL1R-rp, Interleukin-18 receptor alpha, IL-18R-alpha, IL-18Ralpha, CD218a, IL1RRP, IL-1Rrp

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 0.1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

62.7 kDa (550aa)

Additionnal Information

Interleukin-18 receptor alpha, Interleukin-18 receptor 1, Interleukin 18 receptor alpha, Interleukin 18 receptor 1, IL-1RRP, IL1R-rp, IL1RRP, IL-18R-alpha, IL-18Ralpha, IL-18R alpha, IL-1 receptor-related protein, IL1 receptor-related protein, IL-1 receptor related protein, IL1 receptor related protein, IL 1RRP, IL 18R alpha, IL 1 receptor-related protein, IL 1 receptor related protein, CDw218a, CD218a, CD218 antigen-like family member A, CD218 antigen like family member A, ATGP3821-10 µg, ATGP3821-20 µg, ATGP3821-50 µg, ATGP3821-100 µg, ATGP3821-250 µg, ATGP3821-500 µg, ATGP3821-1 mg, ATGP3821-010, ATGP3821-020, ATGP3821-050, ATGP3821-100, ATGP3821-250, ATGP3821-500, ATGP3821-01M

References & Citations

Torigoe K., et al, (1997) J. Biol. Chem. 272:25737-25742.; ; Hoshino K., et al, (1999) J. Immunol. 162:5041-5044.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_003846

Uniprot Accession Number

Q13478

Species

Human

N Terminal Sequence

Ala19

AA Sequence

AESCTSRPHI TVVEGEPFYL KHCSCSLAHE IETTTKSWYK SSGSQEHVEL NPRSSSRIAL HDCVLEFWPV ELNDTGSYFF QMKNYTQKWK LNVIRRNKHS CFTERQVTSK IVEVKKFFQI TCENSYYQTL VNSTSLYKNC KKLLLENNKN PTIKKNAEFE DQGYYSCVHF LHHNGKLFNI TKTFNITIVE DRSNIVPVLL GPKLNHVAVE LGKNVRLNCS ALLNEEDVIY WMFGEENGSD PNIHEEKEMR IMTPEGKWHA SKVLRIENIG ESNLNVLYNC TVASTGGTDT KSFILVRKAD MADIPGHVFT RVEPKSCDKT HTCPPCPAPE LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP SRDELTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGKHHHHHH