Recombinant human HLA-DRB1 protein
HLA-DRB1, also known as major histocompatibility complex, class II, DR beta 1 precursor, belongs to the human leukocyte antigen (HLA) class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins to T helper cells. It helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. It is associated with an increased incidence of rheumatoid arthritis. Recombinant human HLA-DRB1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Major histocompatibility complex, class II, DR beta 1, HLA-DRB1, DRB1, HLA-DR1B, HLA-DRB, SS1
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 85% by SDS-PAGE
Molecular Weight
24 kDa (207aa)
Additionnal Information
References & Citations
De Silvestri A., et al. (2017) Autoimmun Rev. 16:1230-1236.; ; Riberdy JM., et al. (1992) Nature. 360:474-477.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 30% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_002115
Uniprot Accession Number
Q29974
Species
Human
N Terminal Sequence
Ala
AA Sequence
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