Recombinant human IFN-gamma R1/IFNGR1 protein

IFNGR1, also known as interferon gamma receptor 1, is a member of the hematopoietic cytokine receptor superfamily. It is a receptor that binds interferon-gamma, the sole member of interferon type II. It induces the rapid dimerization of chains, thereby forming a site that is recognized by the extracellular domain of IFNGR2. It is expressed in a membrane-bound form in many cell types, and is over-expressed in tumour cells. Its signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6. It is crucial for host defence against mycobacterial infections. It is associated with susceptibility to pulmonary tuberculosis (TB) . Recombinant human IFNGR1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Interferon gamma receptor 1, IFNGR1, CD119, IFNGR, IMD27A, IMD27B, IFN-gamma receptor 1, CDw119, Interferon gamma receptor alpha-chain, IFN-gamma-R-alpha

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

26.6 kDa (234aa)

Additionnal Information

IFN-g R1, Interferon gamma receptor 1, IFNGR1, CD119, IFNGR, IMD27A, IMD27B, ATGP3807-10 µg, ATGP3807-20 µg, ATGP3807-50 µg, ATGP3807-100 µg, ATGP3807-250 µg, ATGP3807-500 µg, ATGP3807-1 mg, ATGP3807-10, ATGP3807-20, ATGP3807-50, ATGP3807-100, ATGP3807-250, ATGP3807-500, ATGP3807-1

References & Citations

Shamsi M., et al. (2016) Acta Microbiol Immunol Hung. 63:93-101.; ; Bach EA., et al. (1997) Annu Rev Immunol. 15:563-591.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_000407

Uniprot Accession Number

P15260

Species

Human

N Terminal Sequence

Glu18

AA Sequence

EMGTADLGPS SVPTPTNVTI ESYNMNPIVY WEYQIMPQVP VFTVEVKNYG VKNSEWIDAC INISHHYCNI SDHVGDPSNS LWVRVKARVG QKESAYAKSE EFAVCRDGKI GPPKLDIRKE EKQIMIDIFH PSVFVNGDEQ EVDYDPETTC YIRVYNVYVR MNGSEIQYKI LTQKEDDCDE IQCQLAIPVS SLNSQYCVSA EGVLHVWGVT TEKSKEVCIT IFNSSIKGHH HHHH