Recombinant human SIRP beta 1/CD172b protein
SIRPB1, also known as signal-regulatory protein beta-1 isoform 1, is a type I transmembrane protein of SIRP superfamily. It is an immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein also participates in the recruitment of tyrosine kinase SYK. And it acts as an activating isoform of SIRP alpha molecules that recruit SHP-1 and SHP-2 protein tyrosine phosphatases and activate counterparts, whose engagement couples to protein tyrosine kinases. Recombinant human SIRPB1 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Signal-regulatory protein beta-1 isoform 1, SIRPB1, CD172b, SIRP-BETA-1
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
38kDa (348aa)
Additionnal Information
References & Citations
Liu Y., et al, (2005) J Biol Chem. 280:36132-36140.; ; Gaikwad S., et al, (2009) Am J Pathol. 175:2528-2539.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_006056
Uniprot Accession Number
O00241
Species
Human
N Terminal Sequence
Glu30
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