Recombinant human DR6/TNFRSF21 protein

TNFRSF21, also known as tumor necrosis factor receptor superfamily member 21, is a transmembrane protein in the TNF receptor superfamily. It promotes apoptosis through the activation of NF-kappa-B pathway. Binding of N-terminal APP (N-APP) and TNFRSF21 triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) . This protein plays a role in signaling cascades triggered by stimulation of T-cell receptor. Recombinant human TNFRSF21 protein, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.