Recombinant human DR6/TNFRSF21 protein
TNFRSF21, also known as tumor necrosis factor receptor superfamily member 21, is a transmembrane protein in the TNF receptor superfamily. It promotes apoptosis through the activation of NF-kappa-B pathway. Binding of N-terminal APP (N-APP) and TNFRSF21 triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) . This protein plays a role in signaling cascades triggered by stimulation of T-cell receptor. Recombinant human TNFRSF21 protein, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Tumor necrosis factor receptor superfamily member 21, TNFRSF21, BM-018, CD358, DR6, Death receptor 6
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 85% by SDS-PAGE
Molecular Weight
60.4 kDa (547aa)
Additionnal Information
References & Citations
Wang Y., et al, (2015) J Mol Neurosci. 56:966-976.; ; Fujikura D., et al, (2017) Nat Commun. 8:13957.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol, 0.1mM PMSF.
Scientific Category
Apoptosis
NCBI Accession Number
NP_055267
Uniprot Accession Number
O75509
Species
Human
N Terminal Sequence
Gln42
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