Recombinant human AICL/CLEC2B protein

CLEC2B, also known as C-type lectin domain family 2 member B, is a type-2 transmembrane member of the C-type lectin-like receptor (CTLR) family. They play diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. This protein may function as a cell activation antigen. It has variant roles such as activating receptor that triggers TNF production, NK cell mediated lysis and interactions between activated and resting NK cells. Recombinant human CLEC2B protein, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

C-type lectin domain family 2 member B, Activation-induced C-type lectin, C-type lectin superfamily member 2, IFN-alpha-2b-inducing-related protein 1, AICL, CLECSF2, IFNRG1, HP10085IFNRG1

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

41.7 kDa (366aa)

Additionnal Information

AICL, CLEC2B, C-type lectin domain family 2 member B, CLEC2B, AICL, CLECSF2, HP10085, IFNRG1, ATGP3797-10 µg, ATGP3797-20 µg, ATGP3797-50 µg, ATGP3797-100 µg, ATGP3797-250 µg, ATGP3797-500 µg, ATGP3797-1 mg, ATGP3797-10, ATGP3797-20, ATGP3797-50, ATGP3797-100, ATGP3797-250, ATGP3797-500, ATGP3797-1

References & Citations

Pollitt AY., et al, (2010) Blood. 115:2938-2946.; ; Hughes CE., et al, (2013) J Biol Chem. 288:5127-5135.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_005118

Uniprot Accession Number

Q92478

Species

Human

N Terminal Sequence

Ala

AA Sequence

ADPKLTRDSQ SLCPYDWIGF QNKCYYFSKE EGDWNSSKYN CSTQHADLTI IDNIEEMNFL RRYKCSSDHW IGLKMAKNRT GQWVDGATFT KSFGMRGSEG CAYLSDDGAA TARCYTERKW ICRKRIHLEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHH