Recombinant human PP2C gamma/PPM1G protein
PPM1G, as known as protein phosphatase 1G, is a member of the PP2C family of Ser/Thr protein phosphatases that is negative regulators of cell stress response pathways. This enzyme localizes to the cytoplasm and is widely expressed, with most abundant expression detected in testis, skeletal muscle and heart. It is necessary for the dephosphorylation of pre-mRNA splicing factors, which is an important process for the formation of the functional spliceosome. Recombinant human PPM1G protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by BCA assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
61.4 kDa (566aa)
Additionnal Information
References & Citations
Travis SM., et al. (1997) FEBS Lett. 412 (3) :415-9.; ; Brautigan D.L., et al. (2005) Biochemistry. 44 (33) :11067-73.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl , 0.1mM PMSF
Scientific Category
Cell Cycle
NCBI Accession Number
NP_817092
Uniprot Accession Number
O15355
Species
Human
AA Sequence
Frequently Asked Questions
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