Recombinant human IL-5R alpha/IL5RA protein
IL5RA, also known as interleukin-5 receptor subunit alpha, is a subunit of the Interleukin-5 receptor. The alpha chain binds to IL5. It generates soluble secreted forms which function as IL-5 antagonists and promotes the differentiation of basophils and B cells. This protein plays also a roll of T-cell-derived cytokine which is important in the development of asthma for the lerminal differentiation, activation and survival of committed cosinophil precursors. Recombinant human IL5RA protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Interleukin-5 receptor subunit alpha isoform 1, IL5RA, IL-5R subunit alpha, IL5R, IL-5 receptor subunit alpha, HSIL5R3, CDw125, CD125
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
37.8 kDa (331aa)
Additionnal Information
References & Citations
Khorasanizadeh M., et al, (2016) Int Rev Immunol. 35:294-311.; ; Van Rensburg IC, et al, (2017) Oncotarget. 8:2037-2043.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_000555
Uniprot Accession Number
Q01344
Species
Human
N Terminal Sequence
Ala
AA Sequence
Frequently Asked Questions
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