Recombinant human Neuropilin 1/NRP1 protein
NRP1, also known as neuropilin-1 isoform a, is a type 1 transmembrane protein. This protein is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor and semaphorin family members. It is a VEGF165 and semaphorin receptor expressed by vascular endothelial cells (EC) and tumor cells. It is a co-receptor for VEGF receptor (VEGFR2) that enhances the binding of VEGF 165 to VEGFR2 and VEGF165-mediated chemotaxis. Also, it plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion. Recombinant human NRP1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Neuropilin-1 isoform a, NRP1, BDCA4, CD304, NP1, NRP, VEGF165R, Vascular endothelial cell growth factor 165 receptor
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
94.8 kDa (843aa)
Additionnal Information
References & Citations
Soker S., et al, (1998) Cell 92:735-745.; ; He Z., et al, (1997) Cell 90:739-751.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol
Scientific Category
Angiogenesis
NCBI Accession Number
NP_003864.4
Uniprot Accession Number
O14786
Species
Human
N Terminal Sequence
Phe22
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Rabbit anti-Oryza sativa subsp. japonica (Rice) CBL1 Polyclonal Antibody
