Recombinant human ST2/IL1RL1 protein
IL1RL1, as known as interleukin-1 receptor-like 1 isoform 1, is and interleukin-1 receptor family glycoprotein that contributes to immune responses. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. Recombinant human IL1RL1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Specifications
Measured by its ability to inhibit proliferation using D10.G4.1 mouse helper T cells. The ED50 range ≤10 ng/mL with Human IL-33.
Product Name Alternative
Interleukin-1 receptor-like 1, Protein ST2, homolog of mouse growth stimulation-expressed, DER4, T1, FIT-1, ST2L, ST2V, IL33R
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Bioactivity
Measured by its ability to inhibit proliferation using D10.G4.1 mouse helper T cells. The ED50 range ≤10 ng/mL with Human IL-33.
Molecular Weight
36 kDa (318aa)
Additionnal Information
References & Citations
Yu XX., et al. (2015) Dig. Dis. Sci. 60:1265-1272.; ; Rolland T., et al. (2014) Int. J. Mol. Sci. 15:23227-23239.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Angiogenesis
NCBI Accession Number
NP_057316.3
Uniprot Accession Number
Q01638
Species
Human
N Terminal Sequence
Lys19
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