Recombinant human CD8 beta protein
CD8B, also known as T-cell surface glycoprotein CD8 beta chain isoform 5, is a cell surface transmembrane glycoprotein. This protein serves as a co-receptor for the T cell receptor (TCR) . It found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. CD8 forms a dimer, consisting of a pair of CD8 chains. The most common form of CD8 is composed of a CD8-alpha and CD8-beta chain. Both members of the immunoglobulin superfamily with an immunoglobulin variable (IgV) -like extracellular domain connected to the membrane by a thin stalk, and an intracellular tail. Recombinant human CD8B, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
T-cell surface glycoprotein CD8 beta chain isoform 5, CD8B, CD8B1, LEU2, LY3, LYT3, P37
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 85% by SDS-PAGE
Molecular Weight
17.8 kDa (158aa)
Additionnal Information
References & Citations
Johnson P. (1987) Immunogenetics 26:174-177.; ; Terry LA. et al., (1990) Tissue Antigens 35:82-91.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_004922.1
Uniprot Accession Number
P10966
Species
Human
N Terminal Sequence
Ala
AA Sequence
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