Recombinant human LRG1 protein
LRG1, also known as leucine-rich alpha-2-glycoprotein, is a member of leucine-rich repeat (LRR) family. It is neutrophilic expressed during granulocyte differentiation. It has been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. It binds directly to the TGF-beta accessory receptor endoglin, which, in the presence of TGF-beta1, results in promotion of the pro-angiogenic Smad1/5/8 signaling pathway. It promotes proliferation and inhibits apoptosis in colorectal cancer cells via RUNX1 activation. It is a key physiological regulator of dendrite complexity of hippocampal pyramidal neurons. It physically interacts with TrkB and attenuates BDNF signaling. Recombinant human LRG1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Leucine-rich alpha-2-glycoprotein, LRG1, HMFT1766, LRG
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
35.4 kDa (321aa)
Additionnal Information
References & Citations
Wang X., et al. (2013) Nature. 499:306-311.; ; O Donnell LC., et al. (2002) J Leukoc Biol. 72:478-485.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_443204
Uniprot Accession Number
P02750
Species
Human
N Terminal Sequence
Ala
AA Sequence
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