Recombinant human Integrin beta 4/CD104 protein

ITGB4, also known as integrin beta-4 isoform 1, is a member of the Integrin beta family. It forms noncovalent heterodimers with Integrin alpha 6 and participates in the formation of epithelial hemidesmosomes. This protein plays a critical structural role in the hemidesmosome of epithelial cells and is required for the regulation of keratinocyte polarity and motility. The heterodimer of them binds to NRG1 and this binding is essential for NRG1-ERBB signaling and binds to IGF1 and this binding is essential for IGF1 signaling. It tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Recombinant human ITGB4 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Integrin beta-4 isoform 1, ITGB4, CD104, GP150

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

77.5 kDa (691aa)

Additionnal Information

Integrin b4, Integrin beta-4 isoform 1, ITGB4, CD104, GP150, ATGP3753-10 µg, ATGP3753-20 µg, ATGP3753-50 µg, ATGP3753-100 µg, ATGP3753-250 µg, ATGP3753-500 µg, ATGP3753-1 mg, ATGP3753-10, ATGP3753-20, ATGP3753-50, ATGP3753-100, ATGP3753-250, ATGP3753-500, ATGP3753-1