Recombinant mouse ACBP/DBI protein
Acbp, also known as Acyl-CoA-binding protein isoform 2, is a diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulatesignal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. Expression of Acbp is significantly induced during adipocyte differentiation. Acbp acts as an acyl-CoA pool former and regulates long-chain fatty acids (LCFA) metabolism in peripheral tissues. Recombinant mouse Acbp protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Acyl-CoA-binding protein, ACBP, Diazepam-binding inhibitor, DBI, Endozepine, EP
Expression System
E.coli
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by absorbance at 280 nm)
Purity
> 95% by SDS-PAGE
Molecular Weight
12.4 kDa (110aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Bouyakdan K., et al. (2015) J Neurochem. 133 (2) :253-65.; ; Manjithaya R., et al. (2010) J Cell Biol. 188 (4) :537-46.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4)
Scientific Category
Neuroscience
NCBI Accession Number
NP_031856
Uniprot Accession Number
P31786
Species
Mouse
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMSQAEFD KAAEEVKRLK TQPTDEEMLF IYSHFKQATV GDVNTDRPGL LDLKGKAKWD SWNKLKGTSK ESAMKTYVEK VDELKKKYGI
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